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Jianguo Cao Selected Research

4- chloro- 3- (5- methyl- 3- ((4- (2- pyrrolidin- 1- ylethoxy)phenyl)amino)- 1,2,4- benzotriazin- 7- yl)phenol

1/2009Development of novel benzotriazines for drug discovery.
3/2008Development of prodrug 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl benzoate (TG100801): a topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degeneration.

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Jianguo Cao Research Topics

Disease

26Neoplasms (Cancer)
01/2022 - 02/2007
10Hepatocellular Carcinoma (Hepatoma)
04/2022 - 01/2013
7Lung Neoplasms (Lung Cancer)
01/2022 - 01/2014
6Ovarian Neoplasms (Ovarian Cancer)
11/2021 - 06/2012
6Liver Neoplasms (Liver Cancer)
01/2020 - 05/2016
4Small Cell Lung Carcinoma (Small Cell Lung Cancer)
09/2018 - 01/2016
3Atherosclerosis
07/2021 - 01/2013
3Carcinoma (Carcinomatosis)
06/2019 - 04/2013
3Stomach Neoplasms (Stomach Cancer)
08/2016 - 01/2013
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
09/2020 - 01/2014
2Carcinogenesis
09/2018 - 07/2015
2Uterine Cervical Neoplasms (Cancer of the Cervix)
05/2012 - 11/2011
2Macular Degeneration (Age-Related Maculopathy)
01/2009 - 03/2008
1Inflammation (Inflammations)
01/2019
1Malaria
01/2019
1Adenoviridae Infections (Adenovirus Infections)
06/2018
1Glioma (Gliomas)
04/2018
1Abdominal Abscess
10/2017
1Appendicitis
10/2017
1Chronic Hepatitis B
05/2017
1Ventilator-Associated Pneumonia
01/2017
1Ischemic Stroke
01/2017
1Neoplasm Metastasis (Metastasis)
07/2015
1Colorectal Neoplasms (Colorectal Cancer)
07/2015
1Hyperlipidemias (Hyperlipidemia)
01/2013
1Choroidal Neovascularization
03/2008
1Edema (Dropsy)
03/2008
1Philadelphia Chromosome
01/2008
1Hypertrophy
07/2006

Drug/Important Bio-Agent (IBA)

10GenisteinIBA
11/2021 - 06/2012
9casticinIBA
04/2022 - 11/2011
5Proteins (Proteins, Gene)FDA Link
06/2019 - 01/2013
4isovitexinIBA
01/2021 - 06/2019
4Superoxide DismutaseIBA
01/2021 - 06/2018
4chrysinIBA
01/2019 - 09/2016
48-bromo-7-methoxychrysinIBA
05/2017 - 05/2016
3FlavonoidsIBA
01/2022 - 01/2016
3Biological ProductsIBA
01/2020 - 06/2012
3DNA (Deoxyribonucleic Acid)IBA
01/2020 - 11/2011
37- difluoromethoxyl- 5,4'- di- n- octylgenisteinIBA
12/2019 - 06/2012
3CytokinesIBA
12/2019 - 05/2016
2AmidesIBA
01/2021 - 01/2020
2MethyltransferasesIBA
01/2020 - 01/2020
2SuspensionsIBA
06/2018 - 01/2014
2Conditioned Culture MediaIBA
11/2016 - 05/2016
2Propidium (Propidium Iodide)IBA
01/2013 - 11/2011
2Reactive Oxygen Species (Oxygen Radicals)IBA
05/2012 - 11/2011
24- chloro- 3- (5- methyl- 3- ((4- (2- pyrrolidin- 1- ylethoxy)phenyl)amino)- 1,2,4- benzotriazin- 7- yl)phenolIBA
01/2009 - 03/2008
1Podophyllotoxin (Condylox)FDA LinkGeneric
01/2022
1TubulinIBA
01/2022
1LignansIBA
01/2022
1Food Additives (Food Additive)IBA
07/2021
1FlavonolignansIBA
01/2021
1Silybin (Lagosa)IBA
01/2021
1Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA
01/2021
1hydnocarpinIBA
01/2021
1alepterolic acidIBA
01/2020
1Thiostrepton (Gargon)IBA
06/2019
1Pharmaceutical PreparationsIBA
01/2019
1artemisinin (artemisinine)IBA
01/2019
1AgarIBA
06/2018
1Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
06/2018
1taxaneIBA
06/2018
1cyclopamineIBA
04/2018
1Cadherins (E-Cadherin)IBA
04/2018
1Twist-Related Protein 1IBA
04/2018
1nasIBA
05/2017
1Hepatitis B e AntigensIBA
05/2017
1Biomarkers (Surrogate Marker)IBA
01/2017
1Triggering Receptor Expressed on Myeloid Cells-1IBA
01/2017
1ApigeninIBA
11/2016
1Phosphotransferases (Kinase)IBA
09/2016
1Sorafenib (BAY 43-9006)FDA Link
09/2016
1Transcription Factors (Transcription Factor)IBA
01/2016
1homocamptothecinIBA
07/2015
1Phosphatidylethanolamine Binding ProteinIBA
07/2015
1Aldehyde Dehydrogenase 1 FamilyIBA
01/2014
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
01/2013
1Lovastatin (Mevacor)FDA LinkGeneric
01/2013
1CholesterolIBA
01/2013
1Ribose (D-Ribose)IBA
01/2013
1Caspase 3 (Caspase-3)IBA
01/2013
1Apolipoproteins E (ApoE)IBA
01/2013
1JNK Mitogen-Activated Protein KinasesIBA
05/2012
1Anti-Inflammatory Agents (Anti-Inflammatories)IBA
05/2012
1Histones (Histone)IBA
11/2011
1Sepharose (Agarose)IBA
11/2011
1Angiogenesis InhibitorsIBA
10/2010
1Tirapazamine (SR 4233)IBA
01/2009
1Benzoates (Benzoate)IBA
03/2008
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
03/2008
1ProdrugsIBA
03/2008
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2008
1src-Family KinasesIBA
02/2007
1AminesIBA
02/2007
1Sclerosing Solutions (Sclerosing Agents)IBA
07/2006

Therapy/Procedure

6Therapeutics
01/2019 - 10/2010
1Appendectomy
10/2017
1Chinese Traditional Medicine (Traditional Chinese Medicine)
05/2012
1Lasers (Laser)
03/2008